Analysis of bone metabolism in B cell-specific CD40 conditional knockoout mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06391
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontology
• Research Institution: Osaka University
• Principal Investigator: FUJIHARA CHIHARU 大阪大学, 歯学研究科, 特任助教(常勤) (00755358)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: CD40 / B細胞 / 骨代謝 / コンディショナルノックアウトマウス / 歯周炎

Outline of Final Research Achievements

In this study, we generated B cell-specific CD40 conditional knockout mice (B cell CD40cKO) to analyze the influence of CD40 on B cells on bone metabolism. B cell CD40cKO mice were smaller compared to control mice. The structure of the trabecular bone of femurs of B cell CD40cKO mice was destroyed. Furthermore, bone mineral density and bone volume were decreased in B cell CD40cKO mice, compared to control mice. Thus, CD40 on B cells is important for maintenance of bone homeostasis. We are currently analyzing the roles of CD40 on B cells under an inflamed condition using periodontitis-induced B cell CD40cKO mice.

Free Research Field

歯学