Generation of odontogenic tumor specific iPSCs in virus integration-, feeder-, and serum- free defined culture and their use for disease model study

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06435
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Hamada Atsuko 広島大学, 病院(歯), 歯科診療医 (30760318)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 歯原性腫瘍iPSC

Outline of Final Research Achievements

We succeeded to establish iPS cells from odontogenic tumor in integration-, serum-, feeder-free condition. Though pathogenic mechanism of odontogenic tumor is unknown, neural crest cells were considered as one of the origins of odontogenic tumor. In order to establish a disease model, we examined how to induce iPSC into neural crest cells in complete serum free condition. We believe that our iPSC derived from odontogenic tumor will contribute to elucidation of the pathogenesis of odontogenic tumor and elucidation of onset mechanism.

Free Research Field

口腔外科