Development of non-invasive MRI assessment for chronic thromboembolic pulmonary hypertension

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06478
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Yamasaki Yuzo 九州大学, 大学病院, 医員 (00643347)
• Research Collaborator: Nagao Michinobu 東京女子医科大学, 画像診断学核医学講座, 准教授 ; Abe Kohtaro 九州大学, 大学院医学研究院循環機内科, 助教 ; Hosokawa Kazuya 九州大学, 大学病院, 医員 ; Horimoto Koshin 九州大学, 大学病院, 医員 ; Kamitani Takeshi 九州大学, 大学院医学研究院臨床放射線科, 助教 ; Sagiyama Koji 九州大学, 大学院医学研究院臨床放射線科, 助教 ; Yabuuchi Hidetake 九州大学, 大学院医学研究院保健学科, 教授 ; Honda Hiroshi 九州大学, 大学院医学研究院臨床放射線科, 教授
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: MRI / 肺高血圧 / 肺動脈バルーン形成術 / 心室間同期不全

Outline of Final Research Achievements

Cardiac function and interventricular dyssynchrony in chronic thromboembolic pulmonary hypertension were evaluated before and after balloon pulmonary angioplasty (BPA) using cardiac MRI, and compared to the parameters derived from cardiac catheterization, laboratory test, and 6-minute walk test. The decrease in right ventricular volume was correlated with the decrease in pulmonary artery pressure. The possibility of MRI for non-invasive assessment of pulmonary hypertension was shown. The improvement of interventricular dyssynchrony was correlated with the increase of stroke volume. Not only right ventricle but also left ventricle were improved by BPA and the mechanism was revealed.

Free Research Field

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