Elucidation of the mechanism of inhibition of adiponectin expression in adipocytes induced by high-dose osteocalcin

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06484
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Fukuoka Dental College (2016); Kyushu University (2015)
• Principal Investigator: OTANI Takahito 福岡歯科大学, 口腔歯学部, 助教 (80759738)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: オステオカルシン / 脂肪細胞 / ネクロトーシス

Outline of Final Research Achievements

In addition to providing skeletal support, it was recently revealed that the bone is an endocrine organ that produces osteocalcin. Osteocalcin produced in osteoblasts plays an important role in glucose and energy metabolism. We elucidate that osteocalcin promotes the expression of adiponectin facilitating glucose and lipid metabolism and the signaling pathway by which osteocalcin induces adiponectin expression in adipocytes.
In the process, we identified that high-dose osteocalcin inversely abolished the expression of adiponectin, and revealed that high-dose osteocalcin allowed adipocytes to lead to death and a part of the signaling pathway.

Free Research Field

生化学