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2016 Fiscal Year Final Research Report

Role of lipid mediator on periodontal tissue regeneration through Wnt5a expression.

Research Project

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Project/Area Number 15H06493
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontology
Research InstitutionKyushu University

Principal Investigator

Higashi (Hashimoto) Yoko (橋本)  九州大学, 大学病院, 医員 (90755042)

Project Period (FY) 2015-08-28 – 2017-03-31
Keywords間葉系幹細胞分化 / スフィンゴシン-1-リン酸 / Wntシグナル伝達経路
Outline of Final Research Achievements

Sphingosine-1-phosphate (S1P) is known as the signaling sphingolipid and the bioactive lipid mediator that also plays crucial roles in osteogenic differentiation. In the present study, we investigated the involvement of Wnt signaling on S1P-induced osteogenic differentiation of MSC. We particularly paid attention to β-catenin-dependent and -independent Wnt signaling pathways because both signaling pathways regulate bone formation.
We found that S1P up-regulated Wnt5a expression, leading to the induction of LRP5/6 expression, resulting in the increase of β-catenin-dependent Wnt signaling, and thereby promoting MSC differentiation into osteoblast.

Free Research Field

歯周病学

URL: 

Published: 2018-03-22  

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