Elucidation of the signaling mechanism of periostin

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06496
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Collagenous pathology/Allergology
• Research Institution: Saga University
• Principal Investigator: NANRI YASUHIRO (宮内康弘) 佐賀大学, 医学部, 特別研究員 (00382218)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: ペリオスチン / アレルギー / シグナル伝達 / 炎症

Outline of Final Research Achievements

Although it is known that periostin, a matricellular protein, plays a critical role in allergic inflammation, the detailed mechanism of signaling mechanism of periostin is unclear. In this study, we aimed to elucidate the signaling mechanism of periostin in the inflammatory signaling. We obtained preliminary evidence that specific isoform of periostin has the ability of NF-kB activation. We identified a candidate of the periostin receptor on the cell surface. Moreover, we also found the inducible factor downstream of the periostin signaling pathway.

Free Research Field

アレルギー