2016 Fiscal Year Final Research Report
The role of p62 in the HCC initiation and progression
| Project/Area Number |
15H06547
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
Umemura Atsushi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30759585)
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Keywords | 肝癌 / p62 / NRF2 / mTOR |
|---|
| Outline of Final Research Achievements |
p62 is a autophagy receptor and signaling protein that accumulates in premalignant liver diseases such as non-alcoholic steatohepatitis (NASH), and most hepatocellular carcinomas (HCCs). Although p62 has been shown to participate in cancer progression, its role in HCC development was not explored. Here we show that p62 is necessary and sufficient for HCC induction in mice and that its high expression in non-tumor human liver predicts rapid HCC recurrence after curative treatment. High p62 expression is needed for activation of NRF2 and mTORC1, and protection of HCC-initiating cells from oxidative stress-induced death in chronic liver diseases.
|
| Free Research Field |
腫瘍生物学
|
