Combining LOTUS and rehabilitation therapy after for restoration of locomotor function after spinal cord injury in primates.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06593
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: Kondo Takahiro 慶應義塾大学, 医学部(信濃町), 特任助教 (70759886)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: リハビリテーション / LOTUS / マーモセット

Outline of Final Research Achievements

In this study, it was suggested that LOTUS, a novel drug, could extend the corticospinal tract. On the other hand, in small primates, locomotor rehabilitation reconstructed the quadrupedal locomotion function after severe spinal cord injury, and functional neural connections between the cortex and the spinal cord were suggested in the rehabilitation group. However, it was found that bipedal walking does not recover only with rehabilitation treatment. In the future it is important to reconstruct bipedal locomotion by combining the therapies of both, and is currently undergoing combination therapy.

Free Research Field

生理学