Protective role of leukotriene B4 receptor type 2 in acute lung injury

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06604
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology
• Research Institution: Juntendo University
• Principal Investigator: Shigematsu Misako 順天堂大学, 医学(系)研究科(研究院), 非常勤助手 (60760303)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 急性肺傷害 / 脂質受容体 / ロイコトリエン / ニューモライシン / モンテルカスト

Outline of Final Research Achievements

In this study we explored the roles of leukotriene B4 receptor type 2 (BLT2) in the lung using an acute lung injury model induced by a pneumococcal toxin, pneumolysin (PLY).
BLT2 signaling plays important role in protecting against the PLY-induced acute lung injury by suppressing cysteinyl leukotrienes receptor (CysLT1) expression in lung endothelial cells, and by attenuating the susceptibility to PLY-dependently produced cysteinyl leukotrienes. Additionally, CysLT1 antagonists that currently used as anti-asthmatic drugs will be beneficial to treat acute lung injury in the early phase of pneumococcal pneumonia.

Free Research Field

生化学