2016 Fiscal Year Final Research Report
Identification of network related tumor suppressor miRNA in oral cancer
| Project/Area Number |
15H06626
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Nihon University (2016)
Teikyo University (2015) |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Keywords | 口腔癌 / microRNA / ネットワーク解析 / microRNAアレイ解析 / 癌関連遺伝子 |
|---|
| Outline of Final Research Achievements |
We performed miRNA microarray analysis in oral squamous cell carcinoma (OSCC)-derived cell lines. We identified candidate microRNAs for molecular targeting. Our findings may contribute to an understanding of key biologic functions and pathways of certain microRNAs associated with OSCC, and the expression status of TGF-β may play an important role in the progression and prognosis of this disease. In addition, the differential expression status of TGF-β may provide insights into the process of tumorigenicity and for planning new treatment strategies
|
| Free Research Field |
口腔外科学
|
