2016 Fiscal Year Final Research Report
Involvement of immune response in intra oral mechanical hypersensitivity associated with oral mucosa incisions
| Project/Area Number |
15H06647
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Keywords | TRPV2 / TRPA1 / IL-6 / Pain |
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| Outline of Final Research Achievements |
Intra oral injury causes mechanical allodynia. We have reported that increased expression of TRPA1 are involved in mechanical allodynia following buccal mucosa incision. But, it is still not unclear the involvement of TRPV2 which accepts a mechanical stimulas and IL-6 which participates in expression of mRNA of TRPA1. So, we performed behavioral testing and immunohistochemistry using a buccal mucosa incision rat. Present findings suggest that increased expressions of TRPV2 in peptidergic TG neurons innervating incisional buccal mucosa are involved in buccal mucosal heat hypersensitivity and mechanical allodynia following the buccal mucosa incision. And, the amount of IL-6 protein released from incisional site was significantly increased on day 1 after buccal mucosa incision.
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| Free Research Field |
歯科補綴学
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