Fast genome-wide detection of RNA genes using coarse-grained structural information

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Osaka University (2016-2017); Kyoto University (2015)
• Principal Investigator: KATO Yuki 大阪大学, 医学系研究科, 助教 (10511280)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: RNA / 遺伝子発見 / ２次構造

Outline of Final Research Achievements

For the purpose of incomplete genomic annotation of non-coding RNAs, here we presented a computational method for detecting structured RNA genes that two organisms share in common in their genomic sequences, which aims to compare their coarse-grained structures. Computational experiments with both simulated and authentic chromosomal data indicate that the proposed method achieves high sensitivity for the detection of structured RNA genes. We conclude that our approach can be useful as a comparative genomic pre-screening of structured RNAs.

Free Research Field

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