2017 Fiscal Year Final Research Report
Oscilatory neural circuit calculation wtih excitation / suppression (E / I) balance modulation model in hippocampus
| Project/Area Number |
15K00413
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Tokushima Bunri University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
梶原 利一 明治大学, 理工学部, 専任准教授 (60356772)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TANEMURA Kentaro 東北大, (連合)農学研究科, 教授 (20332322)
YOSHIMURA Hiroshi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90288845)
MUTOH Hiroki 浜松医科大学, 医学部, 助教 (60443040)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | E/Iバランス / 海馬 / シータ周期 / ガンマ周期 / 膜電位感受性色素 / バルプロ酸 |
|---|
| Outline of Final Research Achievements |
This study aims to clarify how abnormality of E / I balance causes neuronal circuit information processing abnormality with voltage-sensitive dye (VSD) imaging. The precise activation control of E / I was involved in the short-term plasticity caused by the θ - γ cycle in the hippocampal CA 1 field. The observation was published as a paper in the first year. We have been proceeding with further verification in valproic acid administration model but no significant difference could be found with regard to this short term plasticity phenomenon with respect to this θ - γ cycle. Therefore, we focused on extraction of plastic change caused by this phenomenon and carried out research. I believe that basic data on the relationship of E / I balance disorder have been accumulated.
|
| Free Research Field |
神経科学
|
