• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Regulation of DNA repair pathway choice by early DNA damage response factors.

Research Project

  • PDF
Project/Area Number 15K00536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionTohoku Medical and Pharmaceutical University (2016-2017)
Kyoto University (2015)

Principal Investigator

YANAGIHARA Akihiro  東北医科薬科大学, 医学部, 助教 (70423051)

Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsDNA修復 / 放射線 / DNA二重鎖切断
Outline of Final Research Achievements

NBS1 and ATM are DNA damage response factors that are involved in an early step of the cascade. Molecular analysis showed that NBS1 has a novel function to enhance a particular pathway of the ATM signaling and the DSB repair system. Our results suggest that NBS1 might regulate DSB repair via pinpoint control of ATM signaling pathway.

Free Research Field

DNA修復

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi