2017 Fiscal Year Final Research Report
Whether sustained low dose radiation affect the differentiation process in central nerve cells?
| Project/Area Number |
15K00545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 低線量率放射線 / 低線量放射線 / セシウム137 / PC12細胞 / 神経分化 / 神経軸索伸長 |
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| Outline of Final Research Achievements |
Using X ray-irradiation equipment or radioactive cesium gamma-source, the effect of low dose or low dose rate irradiation on the neuronal differentiation process was examined in the cultured cells. A transient low dose X ray-irradiation (100～500 mSv / 5 min) or a chronic gamma-irradiation under very low dose rate (200 mSv / year) slightly promoted the neuronal differentiation process. However, the chronic gamma irradiation under different low dose rate (200 mSv / 5 days) obviously suppressed the process. These results indicate that the low dose irradiation induces the opposite effect on the neuronal differentiation process depending on the dose rate. This study provides the useful information for the investigation of the effect of environmental radiation on the fetus growing with an active neuronal differentiation.
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| Free Research Field |
放射線生物学
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