A novel target receptor of tamoxifen on the breast cancer cell organellar membrane

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00557
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Kyushu University
• Principal Investigator: LIU XIAOHUI 九州大学, 理学研究院, 助教 (60596849)
• Co-Investigator(Renkei-kenkyūsha): SHIMOHIGASHI Yasuyuki 九州大学, 理学研究院, 名誉教授 (00211293)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: タモキシフェン受容体 / タモキシフェン / 抗エストロゲン作用 / オルガネラ膜 / 乳がん細胞

Outline of Final Research Achievements

We have recently found a novel tamoxifen-specific receptor in the endoplasmic reticulum membrane or nuclear envelope in various cells. The purpose of the present study is to identify this tamoxifen receptor substance in a breast cancer cell and also to develop the new anti-estrogen with its inability to bind to such a tamoxifen-receptor. Despite our efforts, we failed in the isolation of any receptor substances present on endoplasmic reticulum membrane this time. On the other hand, we succeeded in identifying several different kinds of candidate receptor proteins, the siRNA knockdown of which attenuated significantly the maximum binding of tamoxifen. Furthermore, we achieved in the design-synthesis of a novel series of compounds that strongly bind to the estrogen receptor, but not to the tamoxifen receptor.

Free Research Field

化学物質影響化学、環境生化学、受容体科学