2017 Fiscal Year Final Research Report
Elucidation of the molecular mechanism of anti-fouling effects organotin compounds focused on nuclear receptors
| Project/Area Number |
15K00560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Suzuka University of Medical Science (2016-2017)
Kinjo Gakuin University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
永瀬 久光 岐阜薬科大学, 薬学部, 教授 (40141395)
中西 剛 岐阜薬科大学, 薬学部, 准教授 (50303988)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 有機スズ化合物 / PPARγ |
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| Outline of Final Research Achievements |
We cloned a short fragment of the PPAR gamma LBD from Leucoraja erinacea, Petromyzon marinus and Patella depressa (LePPARγ, PmPPARγ and PdPPARγ) and investigated the ligand activity of Rosiglitazone, TBT and TPT on the LePPARγ, PmPPARγ and PdPPARγ.Treatment with rosiglitazone, TBT and TPT had no effects on the PdPPARγ. Although the agonist activity of Rosiglitazone for LePRARγ and PmPPARγ is lower than that for human PPARγ, the agonist activity of TBT and TPT for LePRARγ and PmPPARγ is higher than that for human PPARγ. The results suggest that the effects of TBT and TPT via PPARγ in aquatic species were higher than that in human.
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| Free Research Field |
分子毒性学
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