Development of percutaneous absorptive swallowing improving agent corresponding to aging society

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kochi University
• Principal Investigator: Miyamura Mitsuhiko 高知大学, 教育研究部医療学系臨床医学部門, 教授 (70464378)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 嚥下 / サブスタンスP / 経皮吸収

Outline of Final Research Achievements

To address the needs of an aging society, we have tried to develop a percutaneous absorptive form of swallowing improving agents; 10% ginger-formulated white petrolatum ointment and 10% ginger-formulated polyethylene glycol ointment. In the ginger-formulated white petrolatum ointment, the cumulative skin permeation amount of 6-gingerol increased in a time-dependent manner in the skin permeation test. On the other hand, penetration of 6-gingerol could not be detected with ginger-formulated polyethylene glycol ointment. Thus, it was suggested that an oleaginous base was suitable for ginger-formulated ointments. In clinical trials using 10% ginger-formulated white petrolatum ointment, the amount of SP in saliva, which is considered as a biomarker of swallowing function increased from 1 hour after ointment application. Judging from the half-life, it was suggested that the swallowing function improving effect lasted several hours.

Free Research Field

臨床薬理