Regulation of inflammation and energy metabolism by broccoli sprout extract

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00813
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanazawa University
• Principal Investigator: Nagata Naoto 金沢大学, 医学系, 講師 (70456408)
• Co-Investigator(Renkei-kenkyūsha): Iida Noriho 金沢大学, 医学系, 助教 (40705604)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エネルギー代謝 / 肥満 / 機能性食品因子 / 腸内細菌叢 / 慢性炎症

Outline of Final Research Achievements

Glucoraphanin, a phytochemical in broccoli sprouts, attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity in high fat diet (HFD)-fed wild-type mice but not in HFD-fed Nrf2 knockout mice. Glucoraphanin increased uncoupling protein-1 (Ucp-1) protein levels in subcutaneous adipose depots, thereby increased energy expenditure. In addition, glucoraphanin suppressed Desulfovibrionaceae in gut microbiomes of HFD-fed mice, and decreased plasma lipopolysaccharide levels. By promoting fat browning, limiting metabolic
endotoxemia-related chronic inflammation, and modulating
redox stress, glucoraphanin may mitigate obesity, insulin resistance, and nonalcoholic fatty liver disease.

Free Research Field

代謝学