Inhibition of the extracellular export of mature IL-1beta by spice extracts

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Nara Women's University
• Principal Investigator: Ogura Yasunori 奈良女子大学, 生活環境科学系, 教授 (60304557)
• Co-Investigator(Renkei-kenkyūsha): KIKUZAKI Hiroe 奈良女子大学, 生活環境科学系, 教授 (60291598)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 炎症制御 / IL-1β / 香辛料

Outline of Final Research Achievements

We have found that extracts of 4 spices, i.e. Chinese pepper, cinnammon, Chinese star anise and clove inhibit secretion of IL-1beta from macrophages without affecting either of activation of caspase-1, cleavage of pro-IL-1beta or activation of GSDMD. This finding suggested that the extract of these spices inhibits the extracellular transport of mature IL-1beta at the downstream of GSDMD.
We then tested the activity of tanninc acid on the IL-1beta secretion because all these spices were speculated to contains gallotannin. As a result, we have confirmed that commercially available tannic acid specimens has the same activity as the extracts of the spices, but 1,2,3,4,6-pentagalloyl glucose does not. This suggested that a certain molecular species containing galloyl glucose may specifically inhibit the extracellular transport of mature IL-1beta.

Free Research Field

細胞生物学、免疫学