2017 Fiscal Year Final Research Report
Regulation and physiological significance of histamine production in Raoultella ornithinolytica
| Project/Area Number |
15K00822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桑原 知巳 香川大学, 医学部, 教授 (60263810)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Raoultella / ヒスタミン産生 / ヒスチジン / カタボライト抑制 / 酸素ストレス |
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| Outline of Final Research Achievements |
Raoultella orithinolytica is a member of Enterobacteriaceae, which widely distributes the environment including human intestine. In this study, we revealed the mechanism of histamine production in R. ornithinolytica strain AA097. We found that histamine production in R. orithinolytica is under coordinate positive regulation by CRP and Fis. The histamine-producing R. orithinolytica stimurated colonic epithelial cell growth in germ-free mice. We disclosed that histamine plays a role in oxidative stress response in R. orithinolytica.
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| Free Research Field |
細菌学
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