Mechanism of brain aging promotion by stress and diabetes mellitus and its prevention by food components

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: Keiko Unno 静岡県立大学, 薬学部, 准教授 (10106437)
• Co-Investigator(Kenkyū-buntansha): 木村 洋子 静岡大学, 農学部, 教授 (80291152) ; 住吉 晃 東北大学, 加齢医学研究所, 助教 (80612530)
• Research Collaborator: ISHII Sanae ; PERVIN Monira ; NAKAMURA Yoriyuki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ストレス / 脳老化 / テアニン / カテキン / 認知症予防

Outline of Final Research Achievements

(1) Stress-reducing effect was demonstrated in mice and humans that ingested green tea with reduced caffeine, because the stress-reducing effect of theanine was enhanced by the suppression of antagonistic effect of caffeine.
(2) EGCG and its metabolites were investigated for blood-brain barrier permeability and neurite outgrowth action on cultured neurons (SH-SY5Y). We found that both EGCG and its metabolites enhanced the differentiation of nerve cells.
(3) In the senescence-accelerate model mouse (SAMP8), the ratio of Aβ42 to Aβ40 was significantly increased by stress load, suggesting the involvement of stress on the progression of Alzheimer's disease.

Free Research Field

老化生物学