Studies on dietary and exercise therapies against metabolic and locomotive disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00852
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanto Gakuin University
• Principal Investigator: Yamada Tetsuo 関東学院大学, 栄養学部, 教授 (90200724)
• Co-Investigator(Kenkyū-buntansha): 田中 明 女子栄養大学, 栄養学部, 教授 (70171733)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メタボリックシンドローム / ロコモティブシンドローム / 食事療法 / 運動療法

Outline of Final Research Achievements

Protein intake, particularly branched chain amino acids (BCAAs), and exercise have opposing actions on insulin secretion, but the same action on protein anabolism. We examined the effects of BCAA-rich fat-free milk intake and/or exercise on levels of insulin secretion and indices related to muscle protein metabolism in order to assess the potency of dietary and exercise therapies against metabolic and locomotive disorders.
Adult male or female volunteers participated in the metabolic studies. Urinary C-peptide immunoreactivity excretion and serum insulin levels were significantly higher, but urinary 3-methyl-histidine excretion levels were significantly lower with low urinary catecholamine excretion in the fat-free milk-containing diet than in the control diet. These findings were reduced by exercise with high urinary catecholamine excretion. Fat-free milk intake enhanced insulin secretion and suppressed muscle protein degradation, but these effects are attenuated by exercise.

Free Research Field

運動生理・栄養学