The preventive effects of carotenoids on sarcopenia; a longitudinal study focused on the interactive effects with smoking

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Aichi Shukutoku University
• Principal Investigator: ANDO FUJIKO 愛知淑徳大学, 健康医療科学部, 教授 (90333393)
• Co-Investigator(Kenkyū-buntansha): 大塚 礼 国立研究開発法人国立長寿医療研究センター, NILS-LSA活用研究室, 室長 (00532243)
• Co-Investigator(Renkei-kenkyūsha): SHIMOKATA Hiroshi 名古屋学芸大学, 大学院・栄養科学研究科, 教授 (10226269) ; KATO Yuki 愛知淑徳大学, 健康医療科学部, 教授 (20329650) ; YUKI Atsumu 高知大学, 教育研究部人文社会科学系, 講師 (00623224)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: サルコペニア / カロテノイド / 喫煙 / 筋量 / 縦断研究 / 中高年

Outline of Final Research Achievements

Although smoking is a well-known risk factor of sarcopenia, the mechanism remains unclear. If peroxidation is involved, anti-oxidants such as carotenoids might have preventive effects on sarcopenia, especially in smoking population. The aim of this study is to clarify the interactive effects of carotenoids and smoking on muscle mass decline with aging. The subjects were the participants in a population-based longitudinal cohort study. Mixed effects models were used to estimate whether carotenoids, smoking and their interaction influenced muscle mass decline with aging. The main outcomes were; smoking showed progressive effects, whereas several serum carotenoids showed preventive effects on muscle mass decline with aging in males, but not in females. Moreover, interaction between beta-cryptoxanthin intake and smoking was observed. Beta-cryptoxanthin intake may prevent the muscle mass decline in male smokers.

Free Research Field

老年医学、疫学