Elucidation of molecular mechanism of anticancer activiity of phytochmicals for chemoprevention and treatment

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K00864
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Nakamura Gakuen College
• Principal Investigator: Nakano Shuji 中村学園大学, 栄養科学部, 教授 (40164248)
• Co-Investigator(Kenkyū-buntansha): 竹嶋 美夏子 中村学園大学, 栄養科学部, 准教授 (00241183) ; 小野 美咲 中村学園大学, 栄養科学部, 講師 (10441726)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 乳がん / フィトケミカル / 抗がん作用 / 一次予防 / がん遺伝子 / アポトーシス / 細胞周期 / シグナル伝達

Outline of Final Research Achievements

We analyzed the molecular mechanism of the antitumor effect of phytochemicals that have been suggested to reduce the risk of breast cancer, and verified their preventive and antitumor effects in animal experiments. Phytochemicals used were isoflavones, dimethoxyresveratrol, sulforaphane, etc., and all showed anticancer activity on breast cancer cells, with the great growth suppression observed in triple negative cells. The anticancer activity was exerted by the modulation of proteins associatd with cell cycle and apoptosis. Moreover, phytochemicals were found to suppress the growth of breast cancer in tumor-bearing mice, thus providing evidence for clinical application from the prevention to the treatment of breast cancer.

Free Research Field

癌分子標的治療　抗癌剤耐性

Academic Significance and Societal Importance of the Research Achievements

本研究により、フィトケミカルによる乳癌の発症予防、再発予防、治療などに関する、さまざまな段階でのエビデンスが得られ、機能性食品や薬剤として応用できれば乳癌罹患率および死亡率の増加を食い止めることができ、ひいては乳癌のみならず多くの癌に適用できる可能性があり、膨大化する医療費の削減などに繋がると考えられる