2017 Fiscal Year Final Research Report
Suppressive effects of dietary antioxidants on inflammation of visceral adipose tissues in diet-induced obese mice
Project/Area Number |
15K00867
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | National Agriculture and Food Research Organization |
Principal Investigator |
KOBORI Masuko 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, ユニット長 (50353941)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | クルクミン / ケルセチン / 内臓脂肪組織 / 慢性炎症 / 肥満 / 免疫 |
Outline of Final Research Achievements |
Inflammation of visceral adipose tissue is known to cause insulin resistance and metabolic syndrome. We examined the effects of dietary antioxidants on inflammation of visceral adipose tissue of diet-induced obese mice. Although the carotenoid β-cryptoxanthin scarcely suppressed the inflammation of epidydimal adipose tissue in diet-induced obese mice, curcumin suppressed the oxidative stress and inflammation on the tissue. We compared genes that were considerably up- or downregulated by curcumin with those altered by anti-oxidative flavonoid quercetin in epidydimal adipose tissue of obese mice. The results illustrated that curcumin suppressed the oxidative stress, ER stress and lipogenesis in the tissue. Quercetin was more effective in inhibiting the inflammation of the epidydimal adipose tissue. Quercetin was suggested to improve the inflammation through improving the lipid metabolism in the liver and reducing the fat accumulation in the tissue.
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Free Research Field |
食品機能性
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