Failure of compensatory elongation of mitral valve: A novel approach for ischemic mitral regurgitation using 3D echocardiography

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01327
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokyo
• Principal Investigator: Daimon Masao 東京大学, 医学部附属病院, 講師 (80343094)
• Co-Investigator(Kenkyū-buntansha): 川田 貴之 東京大学, 医学部附属病院, 助教 (20532526) ; 中尾 倫子 東京大学, 医学部附属病院, 助教 (30597216)
• Research Collaborator: HIROKAWA Megumi 東京大学, 医学附属病院, 特任臨床医 ; KIMURA Koichi 東京大学, 医科学研究所附属病院, 特任助教 ; SAWADA Naoko 東京大学, 医学系大学院, 大学院生 ; ISHIWATA Junpei 東京大学, 医学系大学院, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Echocardiography / Imaging / Valvular heart disease

Outline of Final Research Achievements

Reduced coaptation of mitral valve (MV) is a risk for developing functional mitral regurgitation (MR). We determined if MV leaflet area is associated with MV coaptation zone-area, and to identify the clinical factors associated with mitral leaflet size and coaptation-zone area in patients with the normal left ventricle (LV) systolic function and size, by real-time 3D echocardiography. In 175 patients with normal LV size and ejection fraction, there was a significant relationship between MV leaflet and coaptation-zone areas. MV leaflet area was strongly associated with body surface area (BSA) (r =0.907, p<0.001) rather than LV size and age. In 68 patients, we also found that MV coaptation-zone area/BSA was independently associated with the severity of atherosclerosis assessed by cardio-ankle vascular index (CAVI) (r=-0.964, p<0.001), suggesting atherosclerotic change might reduce MA area resulting in generation of functional MR.

Free Research Field

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