Network Meta-Analysis: Theory and Application to the Medical Technology Assessment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01351
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical engineering assessment
• Research Institution: University of Toyama
• Principal Investigator: ORIGASA HIDEKI 富山大学, 大学院医学薬学研究部(医学), 教授 (20245038)
• Co-Investigator(Kenkyū-buntansha): 手良向 聡 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20359798) ; 野間 久史 統計数理研究所, データ科学研究系, 准教授 (70633486)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メタアナリシス / システマティック・レビュー / 費用対効果 / 薬剤経済 / 心房細動

Outline of Final Research Achievements

Theoretical research included a new statistic for testing the consistency for network-meta-analysis. Further, it tried to correct random-effects models to allow for a small sample using a likelihood-based method. Regarding applied research, we first contrasted existing 8 checklists for network meta-analysis. We published a Japanese translation of the PRISMA-NMA and AMSTAR statement. Secondly, we made a survey of meta-analysis seen in 16-country pharmacoeconomics guidelines. Acceptance rate of the meta-analysis was low in 21%. Thirdly, we evaluated a performance of selected meta-analysis for the foods with function registered in Japan. Finally, we conducted cost-effectiveness analysis of new anticoagulants (DOAC) for atrial fibrillation. Based on the network meta-analysis of relevant randomized trials, we estimated an incremental cost effectiveness ratio (ICER) to be 14,000 to 60,000 US dollar (37,000 US dollar in average), which was considered as reasonable.

Free Research Field

医療統計学