Development of non destructive activation analysis for boron isotope determination of blood samples in BNCT

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical engineering assessment
• Research Institution: Japan Chemical Analysis Center
• Principal Investigator: Oshima Masumi 公益財団法人日本分析センター, その他部局等, 研究員(移行) (40354815)
• Co-Investigator(Kenkyū-buntansha): 熊田 博明 筑波大学, 医学医療系, 准教授 (30354913) ; 後藤 淳 新潟大学, 研究推進機構, 助教 (90370395) ; 伴場 滋 公益財団法人日本分析センター, その他部局等, 研究員(移行) (40544432) ; 畢 春蕾 公益財団法人日本分析センター, その他部局等, 研究員(移行) (80647321) ; 山口 友理恵 公益財団法人日本分析センター, その他部局等, 研究員(移行) (30639977) ; 森本 隆夫 公益財団法人日本分析センター, その他部局等, 研究員(移行) (40544359)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 荷電粒子放射化分析 / ホウ素中性子捕捉療法 / ガンマ線反同時計数

Outline of Final Research Achievements

Boron Neutron Capture Therapy (BNCT) is a radiotherapy for the treatment of intractable cancer. In BNCT precise determination of B-10 concentration in whole blood samples is crucial for control of the neutron irradiation time. We firstly apply Charged Particle Activation Analysis (CPAA) utilizing a proton beam to non-destructive and accurate determination of B-10 concentration. Short-lived 511 keV annihilation gamma-rays have turned out to disturb the quick determination. By a simulation calculation based on the GEANT 4.10.2 code we have derived an optimal configuration of gamma-ray detectors to reduce the 511 keV gamma-rays. We constructed the detector system comprising a Ge detector and a BGO (Bi4Ge3O12) scintillator. We performed an experiment utilizing a proton beam, which proved the system effective in reducing the background by a factor of 1/29-1/41. The technique contributes to a quick determination of B-10 concentration in whole blood samples in the order of hours.

Free Research Field

ガンマ線分光