Toward understanding the neural network abnormalities in cognitive impairment and neuropsychiatric symptoms in epilepsy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: Nishio Yoshiyuki 東北大学, 医学系研究科, 准教授 (90451591)
• Co-Investigator(Kenkyū-buntansha): 岩崎 真樹 国立研究開発法人国立精神・神経医療研究センター, 病院, 部長 (00420018) ; 神 一敬 東北大学, 医学系研究科, 准教授 (20436091) ; 藤川 真由 東北大学, 大学病院, 助教 (80722371)
• Research Collaborator: Hiroaki Hosokawa
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 側頭葉てんかん / QOL / 記憶障害 / 顔認知 / 前頭葉てんかん / 作話

Outline of Final Research Achievements

1. We constructed a health-related QOL model for 150 patients with temporal lobe epilepsy. Higher self-perception of cognitive impairment, lower social function and higher seizure worries were the primary predictors of overall QOL.
2. We investigated face perception abilities in post-surgical patients with left and right anterior lobectomy (ATL) for treatment of drug-resistant temporal lobe epilepsy. Patients with left ATL performed equivalently on the perceptual tasks for front, oblique and noise-masked face images, whereas patients with right ATL performed worse on oblique and noise-masked images compared with on front face images.
3. We published a case series study of confabulation in patients with frontal lobe epilepsy.

Free Research Field

神経内科、精神医学