The effect of motor traning for cognitive function

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01501
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental mechanisms and the body works
• Research Institution: Yamaguchi University
• Principal Investigator: KIDA Hiroyuki 山口大学, 大学院医学系研究科, 講師 (70432739)
• Co-Investigator(Renkei-kenkyūsha): MITSUSHIMA Dai 山口大学, 大学院医学系研究科, 教授 (70264603) ; YAMAMOTO Yui 東北医科薬科大学, 医学部, 助教 (80635087)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: AMPA受容体 / 運動学習 / 環境エンリッチメント / 認知機能

Outline of Final Research Achievements

To investigate the effect of voluntary movement in developmental period for cognitive function, we kept 3 week age mice in the environmental enrichment (EE) for 2 weeks. We examined AMPA receptor expression and Brain drive neurotrophic factor (BDNF) after in cingulate cortex after voluntary movement. The EE grope showed significantly increase of anti-anxiety behavior and inhibitory avoidance (IA) score, and positive correlation between IA score and the amount of movement. In addition, although AMPA receptor expression did not change, BDNF expression significantly increased in the EE group. These results suggest the trophic effect of voluntary movement in developmental period.

Free Research Field

神経科学