Preventive effects of functional lipids on immobilization-induced muscle atrophy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01615
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: The University of Tokyo
• Principal Investigator: Terada Shin 東京大学, 大学院総合文化研究科, 准教授 (00460048)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 中鎖脂肪酸 / 短鎖脂肪酸 / 廃用性筋萎縮 / ユビキチンリガーゼ / ラット

Outline of Final Research Achievements

This study evaluated the effects of the dietary intake of functional lipids on hindlimb casting- and denervation-induced skeletal muscle atrophy in rats. Consequently, our results demonstrated that dietary intake of medium-chain fatty acids partly prevented the immobilization-induced decreases in muscle mass and muscle protein content by inhibiting the ubiquitin-proteasome pathway, suggesting that the functional lipid may be a new nutritional strategy to attenuate immobilization-induced muscle atrophy.

Free Research Field

スポーツ栄養学