2017 Fiscal Year Final Research Report
Effects of mild hyperbaric oxygen on metabolic syndrome
| Project/Area Number |
15K01617
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | メタボリックシンドローム / 軽度高気圧酸素 / 有酸素代謝 / 骨格筋 / Pgc-1α / ラット |
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| Outline of Final Research Achievements |
Effects of mild hyperbaric oxygen at 1.25 atmospheres absolute with 36% oxygen on metabolic syndrome of rats at 5- (growth), 30- (adult), and 40- (eldely) weeks old were examined. Ater 10 weeks of experimental period, blood glucose, adiponectin, and triglyceride levels were measured. In addition, gene expression levels and biochemical properties of the soleus muscle were examined. A growth-related increase in blood glucose and triglycedride levels of metabolic syndrome rats were inhibited by exposure to mild hyperbaric oxygen. The soleus muscle showed an increased levels of Pgc-1α mRNA after exposure to mild hyperbaric oxygen, which were related to an increased muscle oxidative enzyme activity. The effects of mild hyperbaric oxygen decreased when individual rats became old.
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| Free Research Field |
生命科学
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