Role of systemic angiotensin II in exercise-enhanced neurogenesis in adult hippocampus.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01618
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Tottori University
• Principal Investigator: Mukuda Takao 鳥取大学, 医学部, 講師 (60346335)
• Co-Investigator(Kenkyū-buntansha): 古川 康雄 広島大学, 総合科学研究科, 教授 (40209169)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 海馬 / 神経新生 / 血液脳関門 / 血管透過性 / アンギオテンシンII / 血管内皮増殖因子

Outline of Final Research Achievements

Running exercise induced an increased level of angiotensin II (Ang II) in the systemic circulation, which activated the type 1 receptor of Ang II (AT1R) and enhanced adult hippocampal neurogenesis. Further, activation of AT1R stimulated by Ang II promoted the synthesis of a potent neurogenic molecule, vascular endothelial cell growth factor (VEGF) in the hippocampal astrocytes. Along with the neurogenic effect, we found a tendency that Ang II increases vascular permeability of the blood－brain barrier in the hippocampus, amygdala and some cortical areas.

Free Research Field

生理学