Ameliorating Effect of Exercise on Diabetes-Related Inflammation: A Possible Role for Macrophage Hexosamine Biosynthetic Pathway

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01627
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: SHIRATO Ken 杏林大学, 医学部, 助教 (60559384)
• Co-Investigator(Renkei-kenkyūsha): KIZAKI Takako 杏林大学, 医学部, 教授 (00322446)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ２型糖尿病 / 炎症 / Toll様受容体 / シグナル伝達 / ヘキソサミン代謝経路 / O-結合型N-アセチルグルコサミン / 感染防御 / 運動

Outline of Final Research Achievements

To elucidate molecular mechanisms underlying ameliorating effects of exercise on diabetes-related inflammation, we examined crosstalk between the Toll-like receptor (TLR) signaling and hexosamine biosynthetic pathway in macrophages. We obtained the following insights: 1) the hexosamine biosynthetic pathway suppressed rather than promoted the macrophage TLR signaling and pro-inflammatory responses via O-linked N-acetylglucosamine (O-GlcNAc) modification; 2) type 2 diabetic mice showed reduced rather than exacerbated macrophage pro-inflammatory responses, suggesting that type 2 diabetes impaired capability to protect the host from infection; 3) O-GlcNAc modification did not contribute to the diabetes-related suppression of macrophage pro-inflammatory responses; 4) exercise improved macrophage pro-inflammatory responses, which suggested that exercise is beneficial to host defense against infection.

Free Research Field

健康・スポーツ科学