Does polyamine administration affect cardiac structure and function of athletes' heart ?

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01630
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Yamaguchi Maki 東京慈恵会医科大学, 医学部, 准教授 (30271315)
• Co-Investigator(Kenkyū-buntansha): 竹森 重 東京慈恵会医科大学, 医学部, 教授 (20179675) ; 大城戸 真喜子 東京慈恵会医科大学, 医学部, 助手 (30287304) ; 山内 秀樹 東京慈恵会医科大学, 医学部, 講師 (60220224)
• Co-Investigator(Renkei-kenkyūsha): YAMAZAWA Toshiko 東京慈恵会医科大学, 医学部, 准教授 (00282616)
• Research Collaborator: IKEDA Michiaki 東京慈恵会医科大学, 医学部, 訪問研究員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: athletes's heart / polyamine / arrythmia

Outline of Final Research Achievements

Polyamines such as putrescine are poly-cation molecules indispensable for proliferation of the eukaryotic cells. Polyamines are also known as modulators of ion channels regulating physiological excitability of cardiac cells. Therefore, polyamines may play a significant role in the hypertrophy and arrhythmia of athletes' hearts. To examine the effects of oral administration of polyamine, rats were bred for 9 weeks at four combined conditions of presence and absence of 1 mg/ml of putrescine in drinking water and freely accessible wheel for spontaneous running. Putrescine concentration in the cardiac cells increased in the putrescine (+) / exercise (-) group, but not in the putrescine (+) / exercise (+) group. Electrocardiograph and structural parameters of the heart showed no appreciable effect of putrescine administration with and without exercise. Polyamine concentration in the cardiac cells was suggested to be strictly controlled to regulate exercise induced hypertrophy of the heart.

Free Research Field

筋生理学