2017 Fiscal Year Final Research Report
Investigation of the mechanism of the exercise pressor reflex using a selective chemical denervation method.
| Project/Area Number |
15K01642
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | exercise / muscle afferents / cardiac function / blood pressure / TRPV1 |
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| Outline of Final Research Achievements |
Although a certain class of sensory nerves which innervate skeletal muscles are thought to plays an important role for cardiovascular adaptation during exercise, its real role and the precise mechanism have still unknown. Then the roles of a specific muscle afferent nerves for the cardiovascular response to exercise was examined by a selective chemical denervation technique.
Desensitization/denervation of TRPV1-expressing neurons by chronic systemic or sciatic nerve-specific local administration of capsaicin or a potent TRPV1 agonist attenuated tachycardic response during exercise, while pressor response to exercise was not affected. On the other hand, selective denervation of the IB4 positive nerve in the sciatic nerve did not affect tachycardic / pressor response during exercise.
Lastly, a new technique has been developed to measure cardiac contractility and pump function during exercise in rats, which will contribute to the understanding of the role of the exercise pressor reflex.
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| Free Research Field |
Exercise Physiology
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