Studies on heart-bound adiponectin for heart disease suppression and therapeutic effect

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kindai University
• Principal Investigator: INOUE Takao 近畿大学, 医学部, 助教 (00441006)
• Co-Investigator(Kenkyū-buntansha): 竹森 久美子 近畿大学, 農学部, 准教授 (00288888)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 臓器結合型アディポネクチン / 心肥大 / 高血圧

Outline of Final Research Achievements

Researches on adiponectin have been focused on the relationship between adiponectin in blood and diseases. These researches show that adiponectin in blood and diseases have inverse correlation because adiponectin is anti-metabolic syndrome hormone. Recently, we discovered organ-bound adiponectin as a novel adiponectin. We assessed the relationship between heart-bound adiponectin and hypertension or cardiac hypertrophy. The result showed that heart-bound adiponectin, but not serum adiponectin, inversely correlated with cardiac hypertrophy. Further analysis of gene expression in heart showed that there are genes might be involved in hypertension and cardiac hypertrophy via heart-bound adiponectin.

Free Research Field

生活習慣病