Cancer prevention effect of calorie restriction on radiation induded B-cell leukemia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Childhood science (childhood environment science)
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Shang Yi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 研究員(任常) (50533189)
• Research Collaborator: DAINO Kazuhiro ; MORIOKA Takamitsu ; KAKINUMA Shizuko
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: カロリー制限

Outline of Final Research Achievements

It is well known that children are more susceptible to carcinogenic effects of radiation as compared with adults. So that there is a critical need to make efforts for assessing risk and developing prevention strategies for radiation-induced cancer after childhood exposure. Using mouse model, earlier we reported that adult-onset calorie restriction (CR) reduced the risk of late-occurring lymphomas but not early-onset lymphomas. To investigate the mechanism of CR, we established immunohistochemical staining method to diagnose lymphomas into 4 subtypes. Using next generation sequencing method, we analyzed whole exosome sequence of B-cell leukemia samples, found special mutations in this mouse model.

Free Research Field

放射線生物学