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2017 Fiscal Year Final Research Report

Isolation and biological activity of marine natural compounds with bone-resorbing and bone forming properties

Research Project

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Project/Area Number 15K01803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomolecular chemistry
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TERUYA Toshiaki  琉球大学, 教育学部, 教授 (90375428)

Co-Investigator(Renkei-kenkyūsha) Woo Je-Tae  中部大学, 応用生物学部・応用生物科学科 (20272693)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords破骨細胞 / 骨芽細胞 / アルカリホスファターゼ
Outline of Final Research Achievements

Two new pyrrolinone-containing lipopeptides, ypaoamides B and C, were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey’s analysis of acid hydrolysates. Ypaoamides C inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in mouse monocytic RAW264 cells. Aplysin is a known compound derived from Red Alga Laurencia nidifica collected in Okinawa. Aplysin enhanced the Alkaline Phosphatase (ALP) activity, an early osteoblast marker.

Free Research Field

天然有機化合物

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Published: 2019-03-29  

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