Analysis for Biofunction of Ouabagnin as Endogenous Regulator of Blood Pressure Targeting LXR

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01817
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Iwate Medical University (2016-2017); Tohoku University (2015)
• Principal Investigator: TAMURA Satoru 岩手医科大学, 薬学部, 准教授 (30362619)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ウアバゲニン / 肝X受容体 / 生理活性 / 生体分子 / 上皮性ナトリウムチャネル / 集合尿細管細胞 / アグリコン

Outline of Final Research Achievements

Ouabagenin, an aglycone of cardiotonic steroidal glycoside Ouabain, has been thought to be a non-bioactive precursor for biosynthesis of ouabain. In our study, ouabagnin was revealed to show ligandable activity for liver X receptor (LXR). In addition, ouabagenin was disclosed to down-regulate the expression level of epithelial sodium channel (ENaC) on the cells of collecting duct whereas not to lead hepatic steatosis which was normally induced by typical LXR ligands. Thus, ouabagnin is a one of the promising medical seeds as antihypertensive diuretic and useful chemical tool for exploration for LXR. Further investigation is necessary for analysis of the relationship between ouabagenin and ouabain as endogenous factors.

Free Research Field

天然物化学、有機化学、ケミカルバイオロジー