2017 Fiscal Year Final Research Report
An attempt to develop novel CaM kinase phosphatase inhibitors that are effective for suppression of cancer metastasis with low cytotoxicity
| Project/Area Number |
15K01824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
根平 達夫 広島大学, 総合科学研究科, 准教授 (60321692)
石原 康宏 広島大学, 総合科学研究科, 助教 (80435073)
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| Research Collaborator |
HIDE Michihiro 広島大学, 大学院・医歯薬保健学研究科, 教授 (50284188)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | プロテインホスファターゼ / 阻害剤 / スクリーニング / がん転移・浸潤 / 細胞遊走 / 細胞毒性 / 構造機能相関 |
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| Outline of Final Research Achievements |
CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is a Ser/Thr protein phosphatase that belongs to PPM family. Accumulating evidence shows possible involvement of CaMKP in cancer metastasis. In this study, we carried out large-scale screening of chemical library to find CaMKP-specific inhibitors, and investigated a mechanism of action of the inhibition. Subsequently, we showed that some of these inhibitors effectively suppressed migration of breast cancer cells despite the fact that they had no significant toxic effects on the cells. These data suggest that these CaMKP inhibitors or the derivatives are promising lead compounds for the development of novel cancer metastasis inhibitors without significant cytotoxicity.
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| Free Research Field |
生物化学
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