Feedback control of neural response dynamics by a closed-loop electrophysiological technique

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Brain biometrics
• Research Institution: Hokkaido University
• Principal Investigator: Nishikawa Jun 北海道大学, 情報科学研究科, 准教授 (20392061)
• Research Collaborator: TATENO Takashi ; OHTAKA Yuto ; TACHIBANA Yuishi ; HAGA Takeaki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経科学 / 聴覚皮質 / 神経工学 / 生体生命情報学 / 生物・生体工学

Outline of Final Research Achievements

In this study, we proposed a novel method to control neural response characteristics in specific brain regions using closed-loop electrophysiology. First, we analyzed spectro-temporal receptive field (STRF) in each subfield and layer in the rodent auditory cortex (AC) by using flavoprotein fluorescence imaging and local field potential recording. Then, we revealed that STRF of each neuron in freely moving mouse AC were dynamically changed between two different behavioral contexts. Based on the obtained results, we inserted multichannel silicon electrodes which cover various auditory fields and layers, and we succeeded to construct a real-time closed-loop system that can stimulate through arbitrary channels according to the estimated STRFs from the neural recordings.

Free Research Field

神経工学