Multi-components chemical analysis using surface-enhanced Raman spectroscopy with single-molecule sensitivity

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K04592
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nanostructural chemistry
• Research Institution: Kobe University
• Principal Investigator: Sugano Koji 神戸大学, 工学研究科, 准教授 (20372568)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: 表面増強ラマン分光 / 1分子計測 / 金ナノ粒子 / プラズモニクス / プラズモニクス

Outline of Final Research Achievements

The purpose of this project was to develop the analytical method for multi-component identification of molecules based on surface-enhanced Raman spectroscopy using a gold nanoparticle dimer with single molecule sensitivity. Due to the Raman enhancing hotspot with 1 nm nanogap in the single dimer, for the first time, the single oligomer detection and analysis was demonstrated. The dimer identified the several bases and backbone components of the single DNA oligomer. The dynamics of the single oligomer could be analyzed. The oligomer was trapped and stayed at the nanogap hotspot, and fluctuated with rotation.

Free Research Field

マイクロ・ナノシステム