Catalytic Syntheses of Organofluorine Compounds Based on Fluorine-Substituted Complexes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K05414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: University of Tsukuba
• Principal Investigator: FUCHIBE Kohei 筑波大学, 数理物質系, 准教授 (10348493)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 触媒 / フッ素 / カルベン錯体 / 医薬 / 農薬 / ニッケル / 銅

Outline of Final Research Achievements

Organofluorine compounds have increased their importance as pharmaceuticals and agrochemicals especially in recent years. We have focused our attention on difluorocarbene complexes that realize highly efficient syntheses of organofluorine compounds with metal catalysts. It was disclosed that nickel(II) and copper(I) complexes generate the corresponding difluorocarbene complexes and that selective syntheses of isomeric α,α- and β,β-difluorocyclopentanone derivatives, starting from common silyl dienol ethers, were facilitated. The structures which we successfully constructed in this project were commonly found in those of biologically active compounds, leading to development and efficient manufacturing of pharmaceuticals and agrochemicals in future.

Free Research Field

遷移金属錯体