2017 Fiscal Year Final Research Report
Development of partially fluorinated phospholipid bilayer membrane
| Project/Area Number |
15K05558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | リン脂質 / フッ素化 / 膜タンパク質 / パーフルオロアルキル基 / 脂質二分子膜 / タンパク質ー脂質相互作用 |
|---|
| Outline of Final Research Achievements |
Novel partially fluorinated phospholipids have been developed for structural and functional analysis of membrane proteins in vitro. The partially fluorinated phospholipids showed membrane properties and structure significantly different from the corresponding unfluorinated ones. And it has been demonstrated that a model membrane protein in the partially fluorinated phospholipid bilayer adopts nativelike structure and function.
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| Free Research Field |
生体分子科学
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