2017 Fiscal Year Final Research Report
Dynamic information processing in neuronal axons
| Project/Area Number |
15K06722
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Kyoto University (2017)
Doshisha University (2015-2016) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAKABA Takeshi 同志社大学, 脳科学研究科, 教授 (80609511)
|
|---|
| Research Collaborator |
DIAZ-ROJAS Francois 同志社大学, 脳科学研究科, 大学院生
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 軸索終末 / シナプス / パッチクランプ / 小脳 / Ca緩衝 / GABA-A受容体 / 短期シナプス可塑性 / 伝達物質放出 |
|---|
| Outline of Final Research Achievements |
Physiology of an axon and its terminals in the central nervous system remains elusive because of the difficulty to analyze the small size of structures. In this project, we clarified the dynamic regulation mechanism of information processing in the axon and terminals by using the direct patch-clamp recording technique together with local activation of transmitter by a spot laser illumination method. Specifically, we analyzed dynamic regulation mechanisms to control transmitter release from terminals of Purkinje cells and granule cells which mediate fine motor control.
|
| Free Research Field |
神経性物
|
