2017 Fiscal Year Final Research Report
Structural Analysis of glial cells by using high resolution imaging method
Project/Area Number |
15K06734
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | The University of Tokyo |
Principal Investigator |
Iwasaki Hirohide 東京大学, 大学院医学系研究科(医学部), 講師 (30342752)
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Co-Investigator(Renkei-kenkyūsha) |
OKABE Shigeo 東京大学, 大学院医学系研究科, 教授 (60204012)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | グリア細胞 / 微細形態解析 / 電子顕微鏡 / 光学顕微鏡 |
Outline of Final Research Achievements |
In the central nervous system of the mammalian brain, three types of glial cells have been identified; astrocyte, microglia and oligodendrocyte. Among them, oligodendrocyte forms myelin around axons. Other types of glial cells might contribute to the synaptic functions of the brain by affecting the synapse formation/elimination. In this research, I analyzed the precise structure of astrocyte and microglia by using CLEM (Correlative anaylysis of light- and electron- microscopy) method. Particularly, I succeeded the comprehensive three-dimensional reconstruct of the fine protrusions of single microglia.
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Free Research Field |
神経形態学
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