Neural network regulating olfactory functions in mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ISHII Tomohiro 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60549947)
• Co-Investigator(Kenkyū-buntansha): 中田 隆夫 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50218004)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経回路 / 発生工学 / 嗅覚

Outline of Final Research Achievements

To understand how sensory information is processed in the brain, it is important to visualize the neural network processing a particular information. We developed novel transgenic mice and tried to visualize neural connections. Modified DNA recombinase Cre molecules are transmitted to neighboring neurons through synaptic connections. We tested if the transsynaptic Cre molecules could induce DNA recombination in neurons neighboring to the target cells, resulting in fluorescent protein expression in these neurons.

Free Research Field

細胞生物学