2017 Fiscal Year Final Research Report
Developmental mechanism of the posterior septum associated with fear and anxiety
| Project/Area Number |
15K06736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 中隔核 / 恐怖行動 / Dpy19L1 / thalamic eminence |
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| Outline of Final Research Achievements |
We previously observed abnormal innate fear responses in Dpy19L1 knockout (KO) mice. In this study, we found that the posterior septum, which is associated with fear and anxiety, is severely disorganized in adult Dpy19L1 KO mice. Furthermore, the defect in the posterior septum was also observed in embryonic Dpy19L1 KO mice. However, the development of the posterior septum remains unclear. Using in vivo and in vitro studies, we found a novel caudal origin and rostral migratory stream of posterior septal neurons arising from the thalamic eminence (TE), a transient developmental structure at the rostral end of the rodent diencephalon. Finally, we revealed that Dpy19L1 is localized to the ER membrane and regulates neurite extension during development. Our results suggest that Dpy19L1 is involved in development of the posterior septum, possibly by regulating rostral migration of TE-derived posterior septal neurons.
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| Free Research Field |
神経解剖学
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